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Discovery/Reaction Development at the Enzymatic/Synthetic Chemistry Interface
2016-12-20 | 编辑: | 【 】|浏览次数:
    

  报告题目:Discovery/Reaction Development at the Enzymatic/Synthetic Chemistry Interface   

  报 告 人Prof. David B. Berkowitz 

  报告人单位:University of Nebraska Lincoln 

  报告时间:20161222日(星期四)上午9:30  10:30 

  报告地点:能源楼216会议室 

  主持人:王庆刚研究员 

  报告摘要: 

  This talk will trace the evolution of a technique that has been dubbed In Situ Enzymatic Screening (ISES) wherein enzymes act as analytical tools/realtime sensors to assist synthetic chemists in the discovery of new catalytic reaction manifolds of interest and in the identification of useful chiral ligand families. For reactions for which this screening strategy is well suited, one obtains real time information on relative rates and/or enantioselectivity for an array of catalysts being screened in parallel, without the need to draw aliquots or quench the reactions. The nature of the signal readout and information content, as well as colorimetric and miniaturized versions of such bio-analytical screens will be discussed. 

   The application of ISES to the discovery of (i) the first examples of asymmetric allylic amination mediated by Ni(0)-catalysts; the identification of new (ii) bromorhodiation-carbocyclization and (iii) thiocyanopalladationcarbocyclization transformations, as well as (iv) the identification of useful new chiral salen ligands will be presented. Then, the tables will be turned; reporting enzymes will shed their analytical chemistry role and take on asymmetric catalytic roles in promising hybrid chemo/biocatalytic synthetic schemes. 

  报告人简介:   

  Education:  

1990-1991 

Postdoctoral Research, Yale University (Samuel J. Danishefsky, Mentor) 

1990 

Ph.D., Harvard University (Steven A. Benner, Thesis Advisor) 

1986-1990 

Traveling Scholar, Eidgenössische Technische Hochschule (ETH), Zürich, Switzerland 

1982 

B.S., University of Chicago 

  Scientific/Administrative Leadership:  

2015 

Division Director, Division of Chemistry, National Science Foundation 

2011-2013 

National Science Foundation-CHE Chemistry of Life Processes (CLP) Program Lead 

2010-2013 

National Science Foundation-CHE Chemical Synthesis (SYN) Program Officer 

2012 

NSF Representative/Administrator - NSF/NASA Joint Workshop – “Alternative Chemistries of Life: Empirical Approaches.” – April 1-4 Washington DC [NASA Administrators-Michael New; Mary Voytek; Workshop Organizers: David Lynn (Emory), Cynthia Burrows (Utah), E. Virginia Armbrust (U. Washington)] 2 

2011-2012 

NSF MPS Directorate Distinguished Lectureship Committee – CHE Representative [organized visits of Emily Carter (Princeton), Carolyn Bertozzi (UCB)] 

2004-2008 

American Heart Association, Inaugural Bioengineering and Biotechnology Study Section, Co-Chair (Spring 2007, 2008) 

    

 
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